Endocrine Abstracts

Introduction and objectives: Hyperglycemia is present in about 25% of hospitalized patients. His control is common deficient. Consequently it increases the average stay, infection rates and mortality. In order to improve we present a comprehensive protocol.Methods: We developed algorithms of subcutaneous insulin therapy for non-critical patients, insulin therapy i.v. for critical patients, management of hypoglycemia, fasting situations, diabetic ketoacid...

Graves’ disease is one of the multiple autoimmune diseases that have been reported in HIV-infected patients. With the upsurge of highly active anti-retroviral therapy (HAART) the incidence of autoimmune diseases in HIV-infected patients is increasing, especially after immune reconstitution. We present a male, 51-year-old, who started complaining with anxiety, sudoresis and palpitations. The laboratory workout revealed hyperthyroidism: TSH <0.02 μU/ml (0.46–4...

Endocrine Connections, 2018, 7(10): 1031–1039 (DOI: https://doi.org/10.1530/EC-18-0296)...

Objectives: To evaluate the prevalence of cardiovascular disease (CVD) and associated risk factors in patients with type 2 diabetes mellitus (T2DM) attended in a rural primary care setting.Methods: Cross-sectional study which included patients with T2DM followed in a rural primary care setting. Data about several cardiovascular risk factors was collected (age, sex, smoking, hypertension and dyslipidemia). Also, data about coronary heart disease (CHD) and...

Introduction: Congenital pituitary stalk interruption syndrome (PSIS) is a rare condition, characterized by the triad (not always complete): absence/hypoplasia of the pituitary stalk, hypoplasia/aplasia of the anterior pituitary and absence or ectopy of the posterior pituitary high signal intensity, on magnetic resonance imaging (MRI). PSIS implies a permanent GH deficiency, in 77% associated with other pituitary hormones deficiencies. The aetiology remains uncertain, but some...

Introduction: Type 1 diabetes mellitus (T1DM) and multiple sclerosis (MS) are organ-specific autoimmune diseases. Their association, first described in a study in Sardinia, left questions about their clustering, clarified by the Familial Autoimmune and Diabetes Study, which showed for the first time an highly increased prevalence of MS in adults with T1DM, reinforced by further epidemiological studies that also revealed increased risk of T1DM in MS patients.<p class="abste...

Introduction: Ectopic thyroid is a rare entity, resulting from developmental defects at early stages of thyroid embriogenesis. It’s prevalence is 1/100 000–300 000 in general population and 1/4000–8000 in patients with thyroid disease. This condition is more common in females, in Asians and may occur at any age, although it’s most common at younger ages. The most frequent location of ectopic thyroid tissue is at the base of the tongue. In 70–75% of cas...

Introduction: The main purpose of this case is to present a case in which the left kurtosis interval of the fertile phase curve, may be evaluated by cheeking the biophysical changing pattern of reproducible methods of viscoelasticity and transparency of the cervical secretion.Case report: This case report included a 24 years old woman who plots a curve in which integrates two biomarkers in relation to the fertile window at the follicular phase. It was re...

Introduction: Hypercortisolism in Cushing’s syndrome (CS) determines increased mortality and morbidity. Hypercortisolism is also present in chronic depressive disorders and stress, where telomere length (TL) is shorter than in controls. We hypothesized that telomere shortening may occur and contribute to premature morbidity in CS.Aim: Investigate TL in CS compared to matched controls, and longitudinally in a subset of CS patients evaluated both with...

Objective: Vitamin D deficiency has been related to extraskeletal manifestations such as insulin resistance, type 2 diabetes mellitus (DM) and obesity. The objective of this study was to assess the prevalence of vitamin D insufficiency and deficiency in a population of patients with prediabetes and with type 2 DM already established, and to see if there were differences according to different parameters.Material and methods: Cross-sectional study, in whi...